At the Cutting Edge of Cardiovascular Sciences: Polygenic Risk Scoring for Coronary Artery Disease

Traditionally, cardiologists have focused on the same 5 cardiovascular risk factors. Preventive cardiology currently uses these factors to determine risk and then prescribes the same therapies to all those at risk. Can we use advances in technology and computation to more deeply characterize our patients, identifying the maximally effective individual therapies to prevent coronary artery disease?


Created by

Houston Methodist Hospital


John Cooke, MD, PhD

John Cooke, MD, PhD

Joseph C. "Rusty" and Carole Walter Looke Presidential Distinguished Chair
Professor and Chair, Department of Cardiovascular Sciences
Director, Center for Cardiovascular Regeneration
Houston Methodist Research Institute

Dr. John P. Cooke is the Chair of the Department of Cardiovascular Sciences at the Houston Methodist Research Institute, Director of the Center for Cardiovascular Regeneration, and Medical Director of the RNA Therapeutics Program in the ...

Li Lai, PhD

Li Lai, PhD

Assistant Professor and Research Scientist, Department of Cardiovascular Sciences, Center for Vascular Regeneration
Houston Methodist Research Institute, Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist

Assistant Research Professor of Cardiovascular Sciences, Academic InstituteAssistant Research Member, Research InstituteHouston MethodistWeill Cornell Medical College

Pradeep Natarajan, MD, MMSC

Pradeep Natarajan, MD, MMSC

Director of Preventive Cardiology, Fireman Endowed Chair in Vascular Medicine, Massachusetts General Hospital
Associate Professor of Medicine, Harvard Medical School

Dr. Pradeep Natarajan is the Director of Preventive Cardiology and the Paul and Phyllis Fireman Endowed Chair in Vascular Medicine at Massachusetts General Hospital, Associate Professor of Medicine at Harvard Medical School, Associate ...